Читать книгу Principles of Virology - Jane Flint, S. Jane Flint - Страница 69

The various components of a virus particle, the nucleic acid genome, capsid protein(s), and in some cases envelope proteins, are often synthesized in different cellular compartments. Their trafficking through and among the cell’s compartments and organelles requires that they be equipped with the proper homing signals (see Chapter 12). Components of virus particles must be assembled at some central location, and the information for assembly must be preprogrammed in these molecules (see Chapter 13). The primary sequences of viral structural proteins contain sufficient information to specify assembly; this property is exemplified by the remarkable in vitro assembly of tobacco mosaic virus from coat protein and RNA (Box 2.1). Successful virus reproduction depends on redirection of the host cell’s metabolic and biosynthetic capabilities, signal transduction pathways, and trafficking systems (see Chapter 14).