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1.2.1.1. Studies with a prenatal onset: the EDEN study (study of pre- and postnatal determinants of child development and health)

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This study (Heude and Forhan 2015) aimed to investigate prenatal and postnatal determinants of child health and development in a French population. Pregnant women at <24 weeks of amenorrhea were recruited to the Poitiers and Nancy university hospitals between 2003 and 2006. Exclusion criteria were: being under 18 years of age, no informed consent, functional illiteracy in French, history of diabetes, plan to change address or no social security coverage.

Of the 3,758 women invited to participate, 2,002 (53%) agreed to enroll in the study. Women with multiple pregnancies were also excluded. With deaths, the number fell to 1,899 infants enrolled at birth. Written informed consent was obtained twice from parents: at enrollment and after the child’s birth.

All variables included in the analysis were collected by means of paper self-completed questionnaires, with the exception of anthropometric measurements, which were assessed by clinical examination, and birth term, which was removed from medical records. The children were then followed up at 4, 8, 12 and 24 months and at five or six years.

Child Psychology

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