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Negative feedback mechanisms

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For each physiological variable there is an optimal value termed the ‘set point’.

For example, the set point for blood glucose is around 5 mmol/l. At this optimal concentration cells throughout the body will have a steady supply of glucose, allowing them to undertake efficient cellular metabolism. The body attempts to maintain each variable as close to its set point as possible by a process called negative feedback. During negative feedback deviations from the set point are minimised and resisted to constrain the variable within its ‘normal range’.

Understanding Anatomy and Physiology in Nursing

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