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Uveoscleral Outflow

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Aqueous humor is not entirely removed by a plexus of collector vessels via the ICA. Some aqueous drains posteriorly into the vitreous humor, anteriorly within the iridal stroma and across the cornea, or exteroposteriorly along a supraciliary–suprachoroidal space into the adjacent sclera (Figure 1.42). The lattermost pathway is called the uveoscleral, or unconventional, outflow pathway (not sensitive to changes in intraocular ocular pressure). The degree of uveoscleral outflow varies remarkably between species, with cats experiencing the least drainage (3%), followed by humans (4–14%), rabbits (13%), dogs (15%), and nonhuman primates (30–65%). In the horse, the uveoscleral pathway may be just as important as the conventional route for aqueous humor removal (Figure 1.43).


Figure 1.42 The majority of aqueous humor flows from the posterior chamber (PC) into the anterior chamber (AC), where it is removed via the ICA by the trabecular meshwork and AAP. Other drainage routes include exchange across the vitreous face (V), iris vessels (I), and corneal endothelium (C), and via the uveoscleral (US) pathway.

Essentials of Veterinary Ophthalmology

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