Читать книгу Population Genetics - Matthew B. Hamilton - Страница 25

 Estimate the frequency of an observed genotype in a forensic DNA typing case.

 Test the null hypothesis that observed and expected genotype frequencies are identical.

 Use Hardy–Weinberg to compare two genetic models for observed phenotypes.

In the previous two sections, we established the Hardy–Weinberg expectations for genotype frequencies. In this section, we will examine three ways that expected genotype frequencies are employed in practice. The goal of this section is to become familiar with realistic applications as well as hypothesis tests that compare observed and Hardy–Weinberg expected genotype frequencies. In this process, we will also look at a specific method to account for sampling error (see Appendix).