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This drug is in a class of its own, and its precise mode of action is unknown. It seems to increase excretion of bile acids in the faeces, so that more cholesterol is broken down in the liver to replenish them. It can lower LDL-cholesterol by up to 10 per cent, but HDL-cholesterol is reduced as well. Triglycerides remain unchanged. Probucal also acts as an antioxidant. Possible side-effects include flatulence, diarrhoea, mild abdominal pain and, very rarely, abnormal heart rhythm.