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1.6 Conclusion and Perspective

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According to Pauling's personal communication revealed by the Nobel Foundation's disclosure, he considered Watson and Crick's Nobel award to be premature. In spite of his opinion, the Nobel Foundation decided to award the Prize to Watson and Crick. This might suggest that Watson–Crick base pairs were very common and meaningful at that time but non-Watson–Crick base pairs were artifact and meaningless. Nowadays, non-Watson–Crick base pairs are becoming common and significant as Pauling perhaps predicted. Now, the day when the essence of nucleic acids becomes beyond the concept of Watson and Crick is coming closer.

Chemistry and Biology of Non-canonical Nucleic Acids

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