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Naoki Sugimoto
Chemistry and Biology of Non-canonical Nucleic Acids
Читать книгу Chemistry and Biology of Non-canonical Nucleic Acids - Naoki Sugimoto - Страница 1
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Вернуться на страницу книги Chemistry and Biology of Non-canonical Nucleic Acids
Оглавление
Страница 1
Table of Contents
List of Tables
List of Illustrations
Guide
Pages
Chemistry and Biology of Non-Canonical Nucleic Acids
Страница 8
Preface
1 History for Canonical and Non-canonical Structures of Nucleic Acids
1.1 Introduction
1.2 History of Duplex
1.3 Non-Watson–Crick Base Pair
1.4 Nucleic Acid Structures Including Non-Watson–Crick Base Pairs
1.5 Perspective of the Research for Non-canonical Nucleic Acid Structures
1.6 Conclusion and Perspective
References
2 Structures of Nucleic Acids Now
2.1 Introduction
2.2 Unusual Base Pairs in a Duplex
2.2.1 Hoogsteen Base Pair
2.2.2 Purine–Pyrimidine Mismatches
2.2.3 Purine–Purine Mismatches
2.2.4 Pyrimidine–Pyrimidine Mismatches
2.3 Non-canonical Backbone Shapes in DNA Duplex
2.4 Branched DNA with Junction
2.5 Multi-stranded DNA Helices
2.6 Structures in RNA
2.6.1 Basic Structure Distinctions of RNA
2.6.2 Elements in RNA Secondary Structures
2.6.2.1 Hairpin Loop
2.6.2.2 Bulge Loop
2.6.2.3 Internal Loop
2.6.3 Elements in Tertiary Interactions of RNA
2.6.3.1 A-Minor Interactions
2.6.3.2 Ribose Zipper
2.6.3.3 T-Loop Motif
2.6.3.4 Kissing-Loop Interaction
2.6.3.5 GNRA Tetraloop Receptor Interaction
2.6.3.6 Pseudoknot Crosslinking Distant Stem Regions
2.7 Conclusion
References
3 Stability of Non-canonical Nucleic Acids
3.1 Introduction
3.2 Factors Influencing Stabilities of the Canonical Duplexes 3.2.1 Hydrogen Bond Formations
3.2.2 Stacking Interactions
3.2.3 Conformational Entropy
3.3 Thermodynamic Analysis for the Formation of Duplex
3.4 Factors Influencing Stabilities of the Non-canonical Nucleic Acids 3.4.1 Factors Influencing Stability of Triplexes
3.4.2 Factors Influencing Stability of Quadruplex 3.4.2.1 G-Quadruplexes
3.4.2.2 i-Motif
3.5 Thermodynamic Analysis for the Non-canonical Nucleic Acids 3.5.1 Thermodynamic Analysis for the Intramolecular Triplex and Tetraplex
3.5.2 Thermodynamic Analysis for the Intermolecular Triplex
3.5.3 Thermodynamic Analysis for the Tetraplex
3.6 Conclusion
References
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