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Ophthalmological Preparations/Miotics and Antiglaucoma Medicines

A sulfonyl chloride attached to an aromatic ring may be formed by oxidation of the thiol.

Discussion. Acetazolamide is formed in just three steps from 5‐amino‐1,3,4‐thiadiazole‐2‐thiol. The sulfonamide is formed from the sulfonyl chloride in the final step. The sulfonyl chloride is formed by oxidation of the thiol. The amide is formed by acetylation of the amine using acetic anhydride.