Читать книгу Routes to Essential Medicines - Peter J. Harrington - Страница 22

Diagnostic Agents/Radiocontrast Media

For a symmetrical molecule, symmetrical disconnections lead back to symmetrical intermediates and are likely associated with the shortest route.

Discussion. Since some amide hydrolysis is likely under iodination conditions, the diamide is formed in the final step by reaction of the diamine with acetic anhydride. The triiodide is formed by iodination of 3,5‐diaminobenzoic acid.