Читать книгу Routes to Essential Medicines - Peter J. Harrington - Страница 25

Draw the structures of three side products which are likely to be formed in the reaction of kanamycin A with two equivalents of benzyl chloroformate. Draw the structure(s) of likely impurities in amikacin as each side product is carried through the amide formation and carbamate hydrogenolysis.

or

Draw the structures of the retrosynthetic analysis of the alternative route to (S)‐4‐amino‐2‐hydroxybutanoic acid from L‐asparagine. List the pros and cons for both routes and select one route as the preferred route.