Читать книгу Routes to Essential Medicines - Peter J. Harrington - Страница 32

Medicines for Pain and Palliative Care/Medicines for Other Common Symptoms in Palliative Care

Medicines for Mental and Behavioral Disorders/Medicines Used in Mood Disorders/Medicines Used in Depressive Disorders

An alkene conjugated to two aromatic rings is often formed by dehydration of an alcohol.

Discussion. The alkene is formed in the final step by dehydration of the tertiary alcohol. The tertiary alcohol is formed by addition of the alkylmagnesium chloride to dibenzosuberone (Grignard Reaction). The alkylmagnesium chloride is formed from 3‐chloro‐N,N‐dimethylpropan‐1‐amine. Dibenzosuberone is formed by cyclization of 2‐phenethylbenzoic acid (Friedel–Crafts Acylation). 2‐Phenethylbenzoic acid is formed by reduction of benzalphthalide. Benzalphthalide is formed from phthalic anhydride and phenylacetic acid.