Читать книгу Routes to Essential Medicines - Peter J. Harrington - Страница 28

Anti‐Infective Medicines/Antibacterials/Antituberculosis Medicines

A 2‐hydroxybenzoic acid is often formed by carboxylation of the phenol (Kolbe–Schmitt Reaction).

Discussion. 4‐Aminosalicylic acid is formed from 3‐aminophenol and carbon dioxide (Kolbe–Schmitt Reaction) (Draw the structure of one side product formed in this reaction. How is pure 4‐aminosalicylic acid isolated from the product mixture?).