Читать книгу Immunology - Richard Coico - Страница 105

For each question, choose the ONE BEST answer or completion.

1 A patient is admitted with multiple bacterial infections and is found to have a complete absence of C3. Which complement‐mediated function would remain intact in such a patient?lysis of bacteriaopsonization of bacteriageneration of anaphylatoxinsgeneration of neutrophil chemotactic factorsnone of the above

2 Complement is required for:lysis of erythrocytes by the enzyme lecithinaseNK‐mediated lysis of tumor cellsphagocytosisantibody‐mediated lysis of bacteriaall of the above

3 Which of the following is associated with the development of SLE‐like symptoms?deficiencies in C1, C4, or C2deficiencies in C5, C6, or C7deficiencies in the late components of complementincreases in the serum C3 levelincreases in the levels of C1, C4, or C2

4 Activated fragments of C5 can lead to all of the following except:contraction of smooth musclevasodilationattraction of leukocytes to a site of infectionattachment of lymphocytes to macrophagesinitiation of formation of membrane attack complex

5 The alternative pathway of complement activation is characterized by all of the following except:activation of complement components beyond C3 in the cascadeparticipation of properdingeneration of anaphylatoxinsactivation of C4regulation by factor H

6 DAF regulates the complement system to prevent complement‐mediated lysis of cells. This involves:dissociation of the C3 convertase complexblocking the binding of the C3 convertase to the surface of bacterial cellsinhibiting the membrane attack complex from binding to bacterial membranesacting as a co‐factor for the cleavage of C3bcausing dissociation of C5 convertase

7 The following activate(s) the alternative pathway of complement:lipopolysaccharidessome viruses and virus‐infected cellsfungal and yeast cell wallsmany strains of Gram‐positive bacteriaall of the above