Читать книгу Understanding Platelet-Rich Fibrin - Richard J. Miron - Страница 7

Foreword

Many important medical/dental discoveries were stumbled upon by pure chance. An example of this is osseointegration, which launched the modern era of dental implants and orthopedic-embedded prostheses. It occurred when orthopedic researcher Per-Ingvar Brånemark found that his titanium research cages in sheep were so completely ingrown with bone that he couldn’t remove them. Similarly, platelet-rich plasma (PRP)/platelet-rich fibrin (PRF) was discovered by the serendipity of observing accelerated and more complete healing in patients who developed hematomas. From that simple observation in the 1980s, the components of the blood clot responsible for the advanced healing have since been determined to be the complete and active growth factors in the alpha granules of viable platelets and several cell adhesion molecules and homing signals in the fibrin clot.

From the early pioneering work in the 1990s to the present, the benchmark of platelet numbers and the functional characteristics of the growth factors, cell adhesion molecules, and homing signals of PRP/PRF have progressed to a mature science and easy-to-use point-of-care devices.

Today, PRP/PRF devices are able to predictably concentrate platelets to known therapeutic levels by a variety of technologic means and to include or exclude leukocytes as per the needs of the wound. PRP/PRF has become a mainstay in bone regeneration in dental implantology and jaw reconstruction, for tendon and joint repair in orthopedics, for soft tissue healing in wound care centers, and in plastic surgery; it has thus benefited hundreds of thousands of patients worldwide.

As one of several individuals who were there at the beginning of the PRP/PRF discovery and who helped to move it along the way somewhat, I am delighted to see that the next generation of clinical researchers as published in Understanding Platelet-Rich Fibrin have brought it to the next level.

This text is written for the clinician to understand how and why PRF promotes healing of both bone and soft tissue as well as how to apply it to improve their own results. Written with a balanced blend of science and clinical applications by the most experienced and accomplished PRP/PRF scientists and clinicians of the day, and beautifully illustrated, Understanding Platelet-Rich Fibrin is a book for this decade that transcends all specialties of dentistry and many of medicine.

Robert E. Marx, DDS

Professor of Surgery and Chief of OMFS

University of Miami

Miller School of Medicine

Miami, Florida