Читать книгу Handbook of Diabetes - Rudy Bilous - Страница 71

Both insulin resistance and β cell dysfunction are early features of glucose intolerance and type 2 diabetes. There has been much debate as to whether one is the primary defect that precedes the other. In practice, the contribution of insulin resistance and β cell dysfunction varies considerably between patients, as well as during the course of the disease. Usually, there is a decline in both insulin sensitivity and insulin secretion in patients who progress from IGT to type 2 diabetes and undoubtedly environmental and genetic factors contribute to this process (Figure 7.11).

Figure 7.19 Pathogenesis of type 2 diabetes. Both genetic and environmental factors contribute to both insulin resistance and β cell failure.