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Preface

It is more than 10 years since the last edition and much has changed in diabetes understanding and therapy. Advances in diabetes technologies such as continuous glucose monitoring have made the use of closed‐loop insulin infusion devices commonplace in many countries. New therapies for type 2 diabetes have led to the concept of personalised management algorithms for patients based upon individual circumstances such as age, weight and presence of complications or comorbidities. Large randomised trials of these treatments have shown benefit in terms of reduction of cardiovascular and renal risk. Diabetic retinopathy is no longer the leading cause of blindness in the working age population in the UK. Bariatric surgery and very low calorie diets have demonstrated the reversibility of type 2 diabetes.

Some things are sadly the same, however, such as the seemingly inexorable rise in prevalence, with the 2019 global figures already exceeding the 2025 predictions of the last edition. Others have fallen short of initial promise, such as islet cell transplantation, and while genetic research into the causes of diabetes has increased our understanding it has not yet been translated into new treatments.

This latest version of the Handbook has been revised and updated incorporating all of these developments and more, and there are new chapters on Cancer and Liver disease. We have tried to maintain the standards and ethos of previous editions. References are again selective but focus on reviews that are freely available wherever possible; key guidance from NICE, SIGN, ADA and other specialist bodies is also included.

Iskandar Idris is a new member of the editorial team and we would like to thank Alistair Lumb for his contribution to the chapters on type 1 diabetes treatment and psychological problems.

The team at Wiley have been notable for their patience. We would like to thank Priyanka Gibbons, Anupama Srikanth, and Jennifer Seward. Their forbearance during the long gestation of this edition is much appreciated. Any errors of commission or omission are, of course, the responsibility of the editors.

The goal with this latest edition is to continue to provide a useful desktop reference for all involved in providing care to people with diabetes.

Rudy BilousRichard DonnellyIskandar Idris