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BOX 1.7 BACKGROUND Descriptive epidemiology and the discovery of human immunodeficiency virus

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Acquired immunodeficiency syndrome (AIDS) was first recognized as a new disease in the United States by physicians in New York, Los Angeles, and San Francisco, who independently noticed that some of the young homosexual male patients in their practices had developed unusual diseases, such as Pneumocystis carinii pneumonia and Kaposi’s sarcoma, which were typically associated with immunosuppressed patients. The first report in the medical literature that described this apparently new syndrome appeared in June 1981, and described five homosexual men in Los Angeles with P. carinii pneumonia. Other reports of a similar syndrome in individuals who injected drugs intravenously soon followed. While these “descriptive” observations raised many questions and incited much anxiety, they also laid the foundation for the subsequent, mechanistically focused work that identified the human immunodeficiency virus as a new human pathogen.

 Centers for Disease Control (CDC). 1981. Pneumo cystis pneumonia—Los Angeles. MMWR Morb Mortal Wkly Rep 30:250–252.

Principles of Virology, Volume 2

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