Читать книгу Principles of Virology, Volume 2 - Jane Flint, S. Jane Flint - Страница 79

A cell may be susceptible to infection if the viral receptor(s) is present and functional. However, the receptor may not be accessible. For example, if the cellular receptor is present only on the basal cell membrane of polarized epithelial cells, a virus that is only exposed to the apical cell surface cannot infect unless it reaches the basolateral surface by some means. Alternatively, if the viral receptor is located between adjacent cells (at the tight junctions), another cell surface protein may be necessary to ferry the virus particle from the exposed cell membrane to the site of the viral receptor (Volume I, Chapter 5). Nonsusceptible (non-receptor-producing) cells can still be infected by alternative routes; for example, virus particles bound to antibodies can be taken up by Fc receptors (see “Immunopathological lesions caused by B cells” in Chapter 4).