Читать книгу Principles of Virology, Volume 2 - Jane Flint, S. Jane Flint - Страница 88

Once virus particles enter the blood or neurons and are dispersed from the primary site of infection, any subsequent reproduction requires invasion of other cells. We have already discussed viral movement into and among neurons to access the brain and spinal cord and will return to this issue in Chapter 5 when we discuss neuropathogenesis resulting from viral infections.

There are three main types of blood vessel-tissue junctions that serve as portals for tissue invasion (Fig. 2.18). In some tissues, the endothelial cells are continuous with a dense basement membrane. At other sites, the endothelium contains gaps, and at still others, there may be sinusoids, in which macrophages form part of the blood-tissue junction. Viruses can traverse all three types of junctions.