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We would like to acknowledge those who helped us complete this book. SP is sincerely grateful to Professor Steve Clarson and Professor Carole Perry who have been the sources of inspiration. SS would like to acknowledge Professor Andrew Harrison, Professor Neil Robertson and Professor Steve Evans for inspiring and enabling her to begin her research in this area. We thank the scientific communities to which we belong: the networks of academics we work and collaborate with and meet at conferences, where we share and develop new ideas, converse and debate. You are a constant source of inspiration for us and for science and engineering in this field to continue to develop. Our collaborators are acknowledged for sharing their wisdom and for the many stimulating discussions over the years. In particular, SS is grateful to Dr Bruce Ward and Professor Steph Baldwin for biological training and insight. We thank many of our current and past group members who have been instrumental in providing the ammunition for this book and for their patience during the writing stages. SS thanks Dr Andrea Rawlings and SP thanks Dr Joe Manning and Dr Mauro Chiacchia for their help with conceptualising some of the complex aspects/mechanisms included in this book. We are grateful to have had support from Ms Yung Hei Tung (Jodie), Dr Andrea Rawlings, Dr Johanna Galloway and Dr Scott Bird for artwork for some of the figures, and Ms Amber Keegan for help with copyright permissions. We also thank various funding agencies for supporting projects where we developed some of the ideas underpinning this book. In particular we thank EPSRC and BBSRC for funding the SynBIM project (EP/P006892/1, http://www.synbim.co.uk and BB/H005412/1). Finally, we thank the reviewers for their insightful feedback: from the initial book proposal, to friends providing comments on early drafts (thanks to Professor Maggie Cusack, Professor Marc Knecht and Dr Fabio Nudelman) and the reviewers of the completed draft. We offer sincere thanks to the publisher for their support and patience.

Finally, we would both like to thank our families. Academia is a challenging and intense career and this is only amplified when one chooses to write a book on top of our other commitments. We are most grateful to our families for their love and support both generally and specifically over the period of writing this book. We both have young children and are especially grateful: SP to his wife Geetanjali and SS to her husband Luke and our parents, for unquestioning childcare that enabled us to achieve this body of work. We are also grateful to our children: Ninaad and Nishaad, and Owen, Alex and Joel, for their interest in our work, for making us laugh and their inquisitive nature that reminds us every day what this is all for.

Siddharth V Patwardhan and Sarah S Staniland

Sheffield, August 2019.