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Example 3.1 Erwin Chargaff's Puzzling Data

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In a key discovery of the 1950s, Erwin Chargaff analyzed the purine and pyrimidine content of DNA isolated from many different organisms and found that the amounts of A and T were always the same, as were the amounts of G and C. Such an identity was inexplicable at the time but helped James Watson and Francis Crick build their double‐helix model in which every A on one strand of the DNA helix has a matching T on the other strand and every G on one strand has a matching C on the other.

Cell Biology

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