Читать книгу Anti-Aging Therapeutics Volume XIII - A4M American Academy - Страница 41

As anti-aging science has progressed on both a molecular and clinical basis, resveratrol, a naturally occurring polyphenol antioxidant, has emerged as a candidate for comprehensive therapy. Laboratory evidence indicates that resveratrol protects skin against the effects of photoaging, and counters age-related diseases via protection against ischemia-reperfusion injury, Alzheimer’s disease, cancer, and diabetes. Resveratrol is a potent phytoestrogen and has potential related benefits and risks. Resveratrol has become a popular supplement in large part due to reports that it is a sirtuin activator, thereby acting as a caloric restriction mimetic and prolonging lifespan. However, questions about the bioavailability of resveratrol remain, clinical evidence is scant, and recent research indicates that resveratrol is not a direct sirtuin activator and does not extend lifespan in mammals. These controversies and the potential clinical role for resveratrol are reviewed.

Keywords: resveratrol, sirtuins, phytoestrogens, wine polyphenols, quercetin