Читать книгу Anti-Aging Therapeutics Volume XIII - A4M American Academy - Страница 44

Resveratrol has a unique range of documented biologic properties. It is a potent antioxidant, as are many polyphenols, though this is better documented in vitro than in human trials. The addition of whole red wine to the diet improves plasma antioxidant status.³ One randomized study compared a 40 mg daily dose of resveratrol for 6 weeks versus placebo, with 10 subjects in each group.⁴ Fasting blood draws were done at intervals for isolation of mononuclear cells which were tested for indices of oxidative and inflammatory stress, with significant reduction in generation of reactive oxygen species (ROS) observed. Additionally, production of pro-inflammatory cytokines and C-reactive protein (CRP), another marker of inflammation, were suppressed in the resveratrol group.

A partial list of additional properties of resveratrol is itemized below:

•Antibiotic

•Multiple enzyme inhibition including cyclo-oxygenase (COX-1 and COX-2)

•Multiple enzyme activation including mitogen-activated protein (MAP) kinase

•Phyto-hormonal

•Protection against ultraviolet radiation

•Anti-cancer: multiple pathways

•Ischemia-reperfusion

•Radiation fibrosis