Читать книгу Anti-Aging Therapeutics Volume XIII - A4M American Academy - Страница 47
Resveratrol and Ischemia-Reperfusion Injury
ОглавлениеOnce an arterial clot is lysed and blood flow restored, a cascade of events ensues which may paradoxically hasten tissue damage. Much of this is mediated by oxidative mechanisms, and a growing body of experimental evidence indicates that there may be significant improvement in tissue survival with administration of resveratrol. (Clinically, this correlates to better outcomes after cardiac events among wine drinkers.) This effect has been reported in experimental models for intestine, brain, spinal cord, skeletal muscle, and heart muscle.9 A stroke model in gerbils demonstrated significant improvement in brain tissue with resveratrol following global ischemia induced by carotid clamping.10 Of particular significance to this study is that it also demonstrated that resveratrol could traverse the blood-brain barrier, with implications for its role in degenerative neurological diseases presuming that adequate blood levels could be achieved. However, the potential role of resveratrol for clinical use in treating ischemia-reperfusion remains to be studied.