Читать книгу Anti-Aging Therapeutics Volume XIII - A4M American Academy - Страница 45

Much of the clinical practice of anti-aging medicine is directed at appearance, and means of countering the visible manifestations of age. The cumulative effects of photodamage in addition to intrinsic aging contribute to an aged appearance, and botanical antioxidants are finding utility in reversing and preventing some of this damage. There is evidence that wine drinkers have fewer signs of photoaging such as actinic keratoses, and consumption of red wine high in polyphenols confers protection against UV damage as measured by minimal erythema dose.⁵ A topical preparation of 1% resveratrol was tested against 1% idebenone, previously advertised as the most potent antioxidant in a skin care product, with the resveratrol formula found to be 17-times more potent as measured by the Oxygen Radical Absorption Capacity (ORAC) test, an industry standard.⁶ Resveratrol appears to provide significant photoprotection though it may work best in combination with other wine polyphenols, as the oral dose from wine consumption would be inadequate to produce effective tissue levels in skin unless it is selectively taken up. Resveratrol appears to hold potential as a cosmeceutical skin care product.