Читать книгу Transporters and Drug-Metabolizing Enzymes in Drug Toxicity - Albert P. Li - Страница 18

A major doctrine in toxicology is the Paracelsus hypothesis:

All things are poison, and nothing is without poison; only the dose makes a thing not a poison.

When Philippus Aureolus Theophrastus Bombastus von Hohenheim (10, 11) made this statement which has become the cornerstone of the field of toxicology, he meant dose to individuals. An often cited example is that drinking too much water, a universally accepted non‐poison, can lead to fatalities due to a phenomenon known as hyponatremia, lowering of plasma sodium concentrations due to over dilution of plasma, leading to hypo‐osmolality‐related fatal events (12, 13).

Based on the Multiple Determinant Hypothesis, I would like to propose a modernization to the Paracelsus doctrine for drug toxicity:

The dose makes the poison, whilst individuals make the dose.