Читать книгу Transporters and Drug-Metabolizing Enzymes in Drug Toxicity - Albert P. Li - Страница 22

The liver’s primary mechanism for metabolizing drugs is comprised of two reaction phases: biotransformation/detoxification (phase I) and conjugation (phase II). In phase I, reactive or polar groups are introduced into xenobiotics. In phase II, reactions these modified compounds are conjugated to polar compounds, which are easier to eliminate from the body.