Читать книгу Transporters and Drug-Metabolizing Enzymes in Drug Toxicity - Albert P. Li - Страница 39

The null allele of CYP2C19 is common, especially in Asians, with a frequency of 13–25% [41]. CYP2C19*2 and CYP2C19*3 are the two most important nonfunctional variants, which occur mainly in Caucasians and Asians, respectively [90]. CYP2C19*2 has a splicing defect while CYP2C19*3 has a premature stop codon. The bioactivation of the antiplatelet drug clopidogrel is dependent largely on CYP2C19 activity [23]. Poor metabolizer patients reportedly are associated with a decreased anticoagulant response and an increased risk of adverse cardiovascular events [91–93]. An isolated number of cases suggested a possible association of CYP2C19 variants with hepatotoxicity of Atrium (phenobarbital, febarbamate, and difebarbamate) [94] and troglitazone [95].