Читать книгу Transporters and Drug-Metabolizing Enzymes in Drug Toxicity - Albert P. Li - Страница 29

The structural alerts for formation of RMs sometimes do not imply actual formation of RMs. In this circumstance, experimental evidence is needed to assess whether a drug candidate is bioactivated to RMs. We discuss some selected experimental approaches here, including covalent binding assay, electrophile trapping experiment and time‐dependent inactivation of CYP450.