Читать книгу Transporters and Drug-Metabolizing Enzymes in Drug Toxicity - Albert P. Li - Страница 40

The most common variant is CYP2B6*6, which harbors two SNP mutations (15631G>T and 18053A>G), causing two amino acid substitutions (Q172H and K262R). CYP2B6*6 is prevalent in different populations with variable frequency [96]. CYP2B6 has been suggested to have clinical implications in HIV therapy [97]. The antiretroviral medication efavirenz is metabolized by CYP2B6. Patients with CYP2B6*6 have decreased CYP2B6 activity and are associated with high plasma levels of efavirenz, which could increase the risk of central neuron system adverse events [92] and hepatic adverse events [48]. CYP2B6*1H and *1J are associated with ticlopidine hepatotoxicity in Japanese populations, possibly due to increased CYP2B6 expression [47].