Читать книгу Transporters and Drug-Metabolizing Enzymes in Drug Toxicity - Albert P. Li - Страница 61

Based on current knowledge, genetic and environmental factors that would enhance the formation of reactive metabolites (CYP3A4 induction), reduction of detoxification (GSH depletion), and increased intracellular accumulation (Pgp inhibition) are potential risk factors for felbamate hepatotoxicity.