Читать книгу Transporters and Drug-Metabolizing Enzymes in Drug Toxicity - Albert P. Li - Страница 62

Flucloxacillin, an isoxazolyl penicillin, is a narrow spectrum antibiotic of the penicillin class that has a broad range of uses in the treatment of Gram‐positive bacterial infections of skin and soft tissue [84, 85], lung [86], urinary tract [87], meningitis [88, 89] and is used as a prophylaxis during surgery [90–92]. Flucloxacillin treatment has been associated with severe hepatotoxicity, resulting in liver failure [93, 94]. A genome wide association study (GWAS) showed an association of flucloxacillin‐induced liver toxicity with the HLA‐B*5701 genotype [95–97].