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Genetic and Environmental

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 Parkinson’s disease: presumed genetic influences but susceptibility (curiously) reduced by smoking.Table 1.1 Population size and doubling times.Source: Data from The Population Reference Bureau, 2015CountryPopulation (millions)No. of births/motherDoubling time (years)Nigeria1076.223India9703.536China12361.867USA2682.0116Japan1261.5289UK601.7433Table 1.2 Incidence and point prevalence.Source: Data from various WHO sources; excludes shingles.DisorderIncidence (100 000/year)Point prevalence /100 000Migraine37012 100Acute stroke Subarachnoid haemorrhage TIA190 15 30900Epilepsy50710Dementia50250Parkinson’s disease20200Chronic polyneuropathies4024Bell’s palsy25Meningitis & infections15Brain tumours1010Trigeminal neuralgia41Multiple sclerosis Motor neurone disease4 290 4Muscular dystrophies16

 MS: genetic susceptibility and geographic location. MS is more common in latitudes around 50°N and S of the equator, and rare in the tropics (0°–23.5° N and S). Clusters of MS cases, for example on the W coast of Ireland.

Neurology

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