Читать книгу Neurology - Charles H. Clarke - Страница 81

 Intravenous immunoglobulin (IVIg) acts by multiple mechanisms, by non‐specific removal of soluble immune factors and possibly interferons. Interference with B‐ and T‐cell interactions, macrophages and complement is important.

 Plasma exchange removes low molecular weight solutes including cytokines and antibodies, especially IgG – quick and effective in GBS, systemic vasculitides and antibody‐mediated encephalitides.

 Interferons act at least in part via modulation of the cytokine network.

 Steroids, oral azathioprine, methotrexate, mycophenolate, and ciclosporin and IV cyclophosphamide immunosuppress non‐selectively.

 IVIg is a replacement therapy in hypogammaglobulinaemias.

Discussion related to therapies in MS: see Chapter 11.