Читать книгу Neurology - Charles H. Clarke - Страница 85

In AD familial hemiplegic migraine two genes identified encode ion channels.

In epilepsy, ion channel mutations can cause benign neonatal convulsions and early‐onset epileptic encephalopathies. In families with generalised epilepsy with febrile seizures plus (GEFS+), seizures may persist beyond early childhood. Mutations of at least four ion channel genes cause GEFS+. Other ion channel mutations have been described, such as malignant migrating partial seizures of infancy.

Paroxysmal dyskinesia, ataxia and hyperekplexia (exaggerated startle reaction) can be caused by channelopathies.