Читать книгу Horse Genetics - Ernest Bailey - Страница 56

The Tobiano mutation, which causes white spotting (Brooks et al., 2008; Chapter 9), occurs well outside the gene thought to be responsible for the tobiano color pattern. In this case, the mutation is a large chromosome rearrangement; approximately 50 megabases (50,000,000 bases) of DNA near the gene have an inverted order when compared with that of other horses. The precise effect of this mutation is not known but thought to affect the function of DNA sequences outside the gene that regulates expression of the gene during development.