Читать книгу Clinical Pharmacology and Therapeutics - Группа авторов - Страница 104

Poorly controlled asthma is associated with increased perinatal mortality. Maternal hypoxia and respiratory alkalosis are the major determinants of foetal distress in asthmatic pregnancies. Inhaled short‐acting β₂‐agonists, inhaled anticholinergics, theophyllines and steroids have good safety records at all stages of pregnancy. There has been limited human data with long‐acting β₂‐agonists but they are still felt to be safe when administered by inhalation.

Pregnancy should not alter the general approach to asthma as described in Chapter 6. It is important to control bronchospasm and avoid prolonged abnormalities of blood gases or acid–base balance. Although asthma management is largely unchanged in pregnancy, the leukotriene antagonists should be avoided as there is extremely limited safety data in human pregnancy.