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Protocols for High-Risk Pregnancies

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Страница 1 Table of Contents List of Tables List of Illustrations Guide Pages Protocols for High‐Risk Pregnancies An Evidence‐Based Approach Страница 8Страница 9 List of Contributors Страница 11 PROTOCOL 1 Alcohol Use in Pregnancy and Lactation Overview Alcohol use during pregnancy Alcohol use during lactation Screening for alcohol use Intervention and referral to treatment Conclusion Suggested reading PROTOCOL 2 Smoking, Vaping, and Nicotine Exposure Clinical significance Pathophysiology Screening for tobacco, nicotine, and vaping exposure Interventions Pharmacotherapy Complications Follow‐up and prevention Suggested reading PROTOCOL 3 Opioid Use, Misuse, and Addiction in Pregnancy and Postpartum Overview Opioid use and misuse Screening and diagnosis Management Labor and delivery Postpartum Conclusion Suggested reading Страница 38Страница 39 PROTOCOL 5 Prenatal Testing for Chromosomal Abnormalities Overview Pathophysiology Diagnosis and screening protocols Prenatal diagnostic testing Cell‐free DNA screening First‐trimester combined screening Nuchal translucency sonography First‐trimester PAPP‐A and hCG Secondary sonographic markers Second‐trimester screening Sonographic detection of major malformations Sonographic detection of minor features of aneuploidy Second‐trimester AFP, hCG, uE3, and inhibin‐A Combined first‐ and second‐trimester screening Conclusion Suggested reading PROTOCOL 6 Fetal Echocardiography Overview Pathophysiology Structural heart disease Diagnosis and work‐up Management Fetal arrhythmias Diagnosis and management Follow‐up Suggested reading PROTOCOL 7 Clinical Use of Doppler Overview Pathophysiology Normal fetal circulation Fetal growth restriction Fetal anemia Preterm labor Cardiac abnormalities Diagnosis Doppler techniques and measurements Cardiac flow velocities Prediction of adverse pregnancy events Fetal growth restriction Rh sensitization Management Congenital heart disease and arrhythmia Fetal growth restriction Fetal anemia Preterm labor Summary Suggested reading PROTOCOL 8 Antepartum Testing Nonstress test Biophysical profile Modified biophysical profile Contraction stress test Umbilical Artery Doppler Velocimetry Indications for antepartum fetal surveillance Suggested reading PROTOCOL 9 Fetal Blood Sampling and Transfusion Clinical significance Cytogenetic diagnosis Fetal infection Fetal anemia Procedure‐related risks Long‐term effects Technique Fetal blood sampling Fetal blood transfusion Postprocedure care Future directions Suggested reading PROTOCOL 10 Preconception Genetic Screening Overview Cystic fibrosis Clinical significance Genetic etiology Screening Spinal muscular atrophy Clinical significance Genetic etiology Screening Hemoglobinopathies Clinical significance Genetic etiology Screening Fragile X syndrome Clinical significance Genetic etiology Screening Tay–Sachs disease and other disorders more prevalent in individuals of Ashkenazi Jewish descent Clinical significance Genetic etiology Screening Management and follow‐up Conclusion Suggested reading Страница 123 PROTOCOL 11 Maternal Anemia Definition Consequences Diagnostic work‐up and treatment Macrocytic anemia Normocytic anemia Microcytic anemia Iron supplementation in pregnancy Treatment of iron deficiency anemia Suggested reading PROTOCOL 12 Hemoglobinopathies in Pregnancy Clinical significance Sickle cell disease Thalassemias Pathophysiology Diagnosis Role of transfusion therapy Pregnancy management of sickle cell disease Preconception counseling Antenatal management Antepartum management (acute pain crisis) Intrapartum management Postpartum management Pregnancy management of thalassemias Suggested reading PROTOCOL 13 Fetal and Neonatal Alloimmune Thrombocytopenia Introduction Diagnosis Management Antenatal Stratum 1 (low risk) Stratum 2 (medium risk) Stratum 3 (high risk) Stratum 4 (extremely high risk) Delivery Postnatal Conclusion Suggested reading {buyButton}

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