Читать книгу Protocols for High-Risk Pregnancies - Группа авторов - Страница 101

The largest volume of cordocenteses and fetal transfusions is done for the evaluation and treatment of fetuses with suspected anemia, usually due to red cell alloimmunization. Besides fetal transfusion, other interventions have been tested to prevent or decrease the severity of fetal anemia in cases of early and severe maternal red cell alloimmunization. These include treatment with either plasmapheresis or IVIG alone or in combination for an attempt at immunomodulation of the disease. There is currently ongoing research into the development of a human IgG1 monoclonal antibody targeting FcRn, the receptor responsible for mediating transfer of IgG across the placenta into the fetal circulation. If these interventions prove successful, they may delay or perhaps eliminate the need for fetal transfusion in some situations.