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Fetal anemia

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Given current technologies and diagnostic tools, most cordocenteses are done in the evaluation of the fetus suspected to be anemic, the overwhelming majority typically due to maternal severe red blood cell alloimmunization. Fetuses at risk of anemia are identified by serial Doppler interrogation of the middle cerebral artery to measure peak systolic velocity. A distant second indication for cordocentesis is parvovirus B19 infection. The literature reports other potential indications for fetal transfusion, including fetomaternal hemorrhage, twin anemia polycythemia sequence, and alpha‐thalassemia, as well as placental and fetal tumors, but because these indications are so rare, none of them has sufficient data to show that fetal transfusion leads to improved outcomes.

Protocols for High-Risk Pregnancies

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