Читать книгу Protocols for High-Risk Pregnancies - Группа авторов - Страница 80

Use of antiprostaglandin medications such as indomethacin for tocolysis results in inhibition of prostaglandin synthase activity and reduction in prostaglandin synthesis, which may constrict the ductus arteriosus. The effect on the ductus arteriosus is gestational age dependent and generally, indomethacin is not used beyond 32 weeks of gestation. A ductus arteriosus effect is not typically seen within the first 48 hours of treatment. Assessment of the velocity within the ductus arteriosus should be considered beyond that time if the patient continues prostaglandin synthase inhibitor therapy. Constriction is typically reversible with discontinuation of antiprostaglandin drugs.