Читать книгу Poisonous Plants and Phytochemicals in Drug Discovery - Группа авторов - Страница 45

The classification of phytotoxins by their biological activities is helpful in drug discovery as researchers can then easily target a metabolite and study it just because it has similar bioactivities to some already known standard drugs. Ascochytin, a phytotoxin from Ascochyta pisi that induces spotting disease on the leaves of peas, is structurally similar to citrinin, a mycotoxin with antifungal activities. As such, ascochytin was regarded as a potential hit for an antifungal [1, 27]. The same is true for griseofulvin, an antibiotic produced by Penicillium griseofulvum as one of its natural products, which is also a known phytotoxin [28].