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The rapid pace of discovery in the genomic and proteomic arenas requires that databases are built in a way that facilitates not just the storage of these data, but the efficient handling and retrieval of information from these databases. Many lessons have been learned over the decades regarding how to approach critical questions regarding design and content, often the hard way. Thus, the continued development of currently existing databases, as well as the conceptualization and creation of new types of databases, will be a critical focal point for the advancement of biological discovery. As should be obvious from this chapter, keeping databases up to date and accurate is a task that requires the active involvement of the biological community (Box 1.3). Therefore, it is incumbent upon all users to ensure the accuracy of these data in an active fashion, engaging the curators in a continuous dialog so that these widely used resources continue to remain a valuable resource to biologists worldwide.