Читать книгу Gastrointestinal Surgical Techniques in Small Animals - Группа авторов - Страница 17

Ischemia interferes with healing of any tissue and especially the gastrointestinal tract. The oxygen delivery to the peripheral tissue depends on the anatomy of the capillaries, vasomotor control, and oxygen saturation. The tissue perfusion depends on the amount of soft tissue trauma and especially trauma to the blood supply of the loop of intestine. The placement of tight sutures interferes with tissue perfusion and may increase the risk of dehiscence, especially in the colon and esophagus (Shikata et al. 1982; Chung 1987; Jonsson and Hogstrom 1992; Thornton and Barbul 1997). Hypovolemia and hypotension are critical factors that divert blood flow to essential organs, and oxygen delivery is also very important for collagen synthesis. A partial pressure of oxygen of at least 40 mmHg is required for collagen synthesis. During a hypovolemic event, the gastrointestinal tract downregulates its own blood flow. Anemia does not interfere with healing as long as the patient has a good cardiac output to compensate (Thompson et al. 2006).