Читать книгу Organofluorine Chemistry - Группа авторов - Страница 21

In recent years, increasing numbers of perfluoroalkyl group‐containing medicines, agrochemicals, and functional materials have been reported [1], in large part due to the development of sophisticated perfluoroalkylating reagents, such as the Ruppert–Prakash, Togni, Umemoto, and Langlois reagents, as reviewed elsewhere in this book. Although synthetic routes to many perfluoroalkylated molecules can now be designed based on reported perfluoroalkylations using these reagents, it remains preferable to employ readily available, inexpensive, multipurpose perfluoroalkyl compounds that can be conveniently stored in the laboratory. In particular, perfluoroalkyl group‐containing building blocks that can be prepared by means of scalable perfluoroalkylation reactions are needed. In this context, we focus here on perfluoroalkylation reactions utilizing perfluorocarboxylic acids and anhydrides as user‐friendly perfluoroalkyl sources. Although several excellent secondary reagents, including the corresponding esters prepared from perfluorocarboxylic acids and anhydrides, are known [2], we will review only methods directly using the carboxylic acids and anhydrides themselves.