Читать книгу The SAGE Encyclopedia of Stem Cell Research - Группа авторов - Страница 130

Somatic cell nuclear transfer (SCNT) is being researched as another possible source of pluripotent stem cells for regenerative medicine treatment of the bladder. SCNT involves implanting a nucleus from a donor somatic cell into an unfertilized oocyte and generating embryonic stem cells from the merging of donor genetic material and oocyte cytoplasm. SCNT is different from reproductive cloning in that cells from a SCNT procedure are generally allowed to develop into a blastocyst that is implanted into a pseudopregnant female, giving rise to a baby that is genetically identical to the donor of the nucleus. In regenerative medicine, cells from a SCNT procedure are propagated in cell culture and not as implantable embryos.

In conclusion, there exist a wide variety of regenerative medicine strategies and techniques for the treatment of the human bladder. Current research focuses on the expansion of existing techniques. Further studies may analyze the effectiveness of generated bladders in the long term. Longitudinal studies may prove useful in providing clinicians with effective and safe treatments.

Krishna S. Vyas

University of Kentucky College of Medicine

Shalin Jyotishi

University of Georgia

See Also: Bladder: Stem and Progenitor Cells in Adults; Neural: Development and Regeneration Potential; Tissue Regeneration: Humans.