Читать книгу The SAGE Encyclopedia of Stem Cell Research - Группа авторов - Страница 324

Ligaments are poorly vascularized and dense structures, and therefore an inflammatory condition can be extensively damaging. An inflammatory response is initiated when the tissue is subjected to stress. The stress can be in the form of repetitive loading of the ligament, within its physiological limits, over an extended period of time. This causes micro-damage within the collagen fibers and can trigger an inflammatory response. On the other hand, when physical activity presents, a sudden overload on the ligament causes a distinct inflammatory response. In this case, healing does not result in full recovery of the functional properties of the tissue. Chronic inflammation can occur when the ligament tissue is not allowed to rest, heal, or recover. Prolonged exposure to loading of the ligament over a long period of time without sufficient rest and recovery also causes cumulative micro-damage.