Читать книгу The SAGE Encyclopedia of Stem Cell Research - Группа авторов - Страница 327

When a ligament is overstretched or torn, it is called a sprain. When separated from the attached bone, it is called an avulsion. Most injuries or ruptures are caused by accidents or sports-related activities and result due to use of a joint beyond its physiological range of motion. Repetitive stress can also cause injury by weakening the ligament and making it more susceptible to damage under physiological conditions. In general, when ligament damage occurs beyond repair (rupture or injury), a healthy ligament is used to reconstruct the damaged one. Although this protocol is mostly successful, it is associated with postoperative pain and loss of function at the donor site. Therefore, stem cells isolated from bone marrow are being used to engineer ligaments that would be used to stabilize a joint and avoid the effects of donor site dysfunction.

Ayesha Irum

Muhammad Saad Faiz

Army Medical College, National University of Sciences and Technology

See Also: Cancer Stem Cells: Overview; Cartilage, Tendons, and Ligaments: Current Research on Isolation or Production of Therapeutic Cells; Cartilage, Tendons, and Ligaments: Stem and Progenitor Cells in Adults.