Читать книгу The SAGE Encyclopedia of Stem Cell Research - Группа авторов - Страница 332

One of the largest impediments to the regeneration of connective tissue is the ability for the new cells to re-form the same three-dimensional structure through the healing process. In order to produce the conditions necessary for mesenchymal stem cells to regenerate cartilage, tendons, and ligaments appropriately, support scaffolds of collagen-based materials, fibrin glue, or synthetic materials are currently being utilized as guides during implantation of stem cells. Additionally, due to the fact that MSCs can form a wide variety of connective tissues, researchers struggle with the ability to specify differentiation and invoke proliferation. Transcription factors that are believed to induce stem cell differentiation into cartilage (Sox5, Sox6, Sox9) and tendon or ligament (Scx) have been identified. Researchers have begun to utilize these transcription factors along with other growth factors in order to potentially increase the effective dose.